The Sciences: Chemistry:
Surprises in Chemistry – Three Examples
by Dr. Dr. Randolph
Riemschneider, B.Fel. Berlin, Germany In "75 Years Chemistry - Re-Reading" [1], it is shown that chemistry is always good for
surprises. For the author it all began with: 1929/36 with yeast [and fermentation (alcohol[1])] in
grandmother´s kitchen [1a] – 1934/35 with glue/gelatin, with some of
the 150 experiments described in the Kosmos-Baukasten (Textbook: "Alles was im Hause ist, untersucht der
Alchemist" ) [2]. Further on in the author's life, the
cited classes of products played a special role and yielded surprising results
– results one would not have expected considering how intensely and for how
many years 1) yeast, 2)
gelatine, and 3) alcohols have been investigated.
A combination of providence and intuition? ad 1) The re-examination of the so-called
"preservation of yeast with different
salts" - practised by the author's grandmother 1929 - led the author to
unknown yeast preparations in 1936/8
[1b]. To these yeast preparations [I, later called Y20] his dog reacted with extraordinary greed. This I, in turn,
triggered feeding experiments with rabbits and generally showed a proven metabolism-enhancing
effect, for example, by the enhancement
of fermentation and respiration in WARBURG experiments [1c]; I was first
applied in the feed industry as Y2000 (based on Y20 [1d]), and was successfully used for many years in cosmetology
in Japan as CYTOCATALYZER: PROJ. XXII
[1e], in medicine in Japan [1s] but also I in 3). ad2) During 1934/35, the author prepared
glue and gelatine from bones
according to a "Kosmos formula" [2]. He learnt more about this in
1936 through his father's brother Fritz, also called Glue Fritz [Leimfritze], as he was a specialist for
the manufacture of natural glues. In 1952, gelatine began to play a role
(together with Y20 made of yeast) in
connection with experiments on: "Sheet
yeast from roll-dried yeast cell preparations (I) for wound dressings and
plasters" [1i]. Since
wound healing was shown to be improved considerable by Y20 yeast preparations (I) in animal experiments, we had developed
sheet-yeast plasters suitable for cutting by subjecting I to roll drying with
addition of gelatine to guarantee an additional wound healing effect
(later also with collagen addition). In the university teaching hospital
of the Brazilian UFSM headed by Professor Dr Mariano da Rocha Filho, many
practical applications of wound healing dressings and plasters with sheet yeast
of + gelatine (collagen) were
carried out on test persons from 1963/70 onwards and received a positive
rating throughout [(1214) in PROJ.XXII] [1e]. In 1953/55, the author, Vogt and
Matter (1382a) investigated the question whether gelatine is useful as a substitute for plasma: partially hydrolysed
gelatines having a molar weight of 14,000 - 17,000 - pH 5.9 - IP 4.6 - with
added NaCl-. 5 % gelatine solutions also containing 1.5 % of fructose and
NaCl/KCl turned out to be useful as a plasma
substitute (use in the medical practice of Dr. Vogt, Berlin, after surgical
procedures and toxaemia) [1k]. The author remembered these
experiments in 2012 when a friend spoke to him about his problems: After
a second prostate operation which was necessary to widen the outlet of the
bladder, blood kept being found in the urine of the patient. Measures
taken to find the cause such as cystoscopy, computer tomography and such like
did not yield any result. In view of the patient's advanced age, the doctors had
advised against surgery. The author recommended to apply gelatine
in form of jelly bears (or gelatine in mixture with Y20). Because of the good water solubility of the gelatine the
author preferred to start with the oral application of gelatine alone. The
experiences collected in 1952, 1963-1970 had been proved to stop bleeding and
haemorrghins by gelatine. His friend followed the author´s
recommendation concerning jelly bears: Bulls
eye! 10-16 jelly bears pro day for one week, later 2-4 weekly: No blood anymore in the urine. The author regarded this result in
his "Re-Reading – 75 Years Chemistry" in Part V-A [1L]. A publication in a medical
periodical seemed the author not to be justified, because only one case (isolated case). It´s now up to
the urologists to continue investigating to confirm or to disprove. Author’s
recommendation: after every prostate or bladder operation the urologist should “prescribe”
prophylactically jelly bears. The author informed the urologist Prof.
Fabricius. ad3) When the author studied literature
on alcoholic fermentation (resulting in ethanol)
and glycolysis (resulting in lactic acid) in the 1930s, he found phosphoric
acid esters as intermediate products in both cases and, in 1934, Lohmann's ATP
(isolated from muscle tissue and described in 1929). This was continued in
lectures during the years 1940 and 1944 under the heading "fermentation
and respiration" [1f], criticising the term energy-rich compound/bound. The
author had found genuine compounds rich in energy at the Institute for
Explosives in Prague in 1943 [1g]. From 1947 to 1949, he worked at Lohmann's
Institute for Physiological Chemistry at Berlin University. Lohmann was the one
who initiated the author's university career [1h]. The class
of alcohols and ethanol itself did not play a very special role in the
chemical investigations of the author until later, approximately from the 1960s
onwards: Applications
in PROJ. XXIII. However, more detailed
information will be provided in PROJ XXVII. This is a result which will surprise every chemist and delight physicians
after having collected in clinical tests on patients for over 20 years:
CELLRYL, Ulcustheraoeuticum [6]. There are further surprises in the
six volumes of Re-Reading" [1] where are treated very different subjects: Diversity is
extremely important for the future of chemistry. This was
a ground rule for the author right from the beginning when he became active in
the field of chemistry and has been ever since. One example: parallel work - on yeast/organ extracts: PROJ. XXII/XXIII - on petrochemistry: on hydrocarbons of the lubricant
type: PROJ. II [1m], - on pest control research: starting in PROJ.
II and then continued from PROJ. VI onwards [1n, p]. It is a
necessity to develop substitutes long before we RUN OUT OF mineral oil,
for example by processing biological synthetics such as those on the basis of wood/cellulose/lignin. We must
not repeat the mistakes made in Germany after the first mineral oil crisis:
alternative energies should have been tackled in our country immediately
after the 1973 crisis and not 30 to 40 years later [3]. In 1973, we had far
fewer obligations – the costly reunification of the two German states and
Berlin [1r] was far off, the European Union had not really started, and we
still had the valuable Deutschmark, i.e. in 1973 we would have gotten many
things at half price. As the
correspondence at the time shows, the US-Americans reacted right away in 1973 [4] and contacted the author who
had experiences with Pitch High Pressure Hydrogenation Plant (700at, 500°C, MoS2)
working there 1943/44: RUHRÖL [5] Bibliography: [1] R.Riemschneider, 75 Years Chemistry - Re-Reading, 2011/14, six Parts:
ISBN, Part I 978-1-882292-28-8, p794; Part II
978-1-882292-34-9, p903; Part III
978-l-882292-35-6, p925; Part
IV 978-l-882292-36-3, p 967; Part
V-A+Part V-B >2000pages (in press). [1a] Part V-A, p354 and p 357 (1195) [1b] Part V-A, p357: (1195) [1c] Part V-A, p362/4: (1206a) –
(1207) [1d] Part II, p540-597 [1e] Part V-A, p434ff [1f] Part V-A, p359: (1198b) – (1199b): author’s lectures [1g] Part I, p374 – 418 [1h] Part IV, p952/3; Part V-A, p 6 [1i] Part V-A, p366/7:
(1214) [1k] Part V-B, p748: (1383a) [1L] Part V-B, p 935: PROJ XXIV 4.10 [1m] Part I, p447ff [1n] Part I, p724ff [1o] Part I, p623 [1r] Part V-A, p 337 [1s] unpublished [2] H.Reinitzer, in [1] Part I, p19: Vita Riemschneider [3] Part
V-A, p 346: ref. (12j) [4] US
commission in Berlin 1973: Part I, p 623/4, 619 [5] Angew.Chem.
B 19, 92/3 (1947) [6]
Inventor: the author, Part II,
p.311-315; Part V-A, p.876, and PROJ.
XIII in Part V-B. [ BWW Society Home Page ] © 2014 The Bibliotheque: World Wide Society |